Drug General Information (ID: DDIQLGPF91)
Drug Name			Bupropion		Drug Info		Blinatumomab		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Antidepressants				Antineoplastics/Cd19 Monoclonal Antibodies

Mechanism of Bupropion-Blinatumomab Interaction (Severity Level: Major)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Bupropion				Blinatumomab
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Bupropion and Blinatumomab

Recommended Action
Management		Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma brain tumor severe hepatic cirrhosis metabolic disorders CNS infections excessive use of alcohol or sedatives addiction to opiates, cocaine, or stimulants diabetes treated with oral hypoglycemic agents or insulin). Bupropion as well as concomitant medications should be initiated at the lower end of the dosage range and titrated gradually as needed and as tolerated. The maximum recommended dosage for the specific bupropion formulation should not be exceeded. Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.

References
1	Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
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6	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
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15	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.