Details of Drug

Drug General Information (ID: D0180)
Drug Name	Bicalutamide
Drug Type	Small molecule
Drug Synonymous	Casodex; Cosudex; Propanamide; Raffolutil; Astra brand of bicalutamide; AstraZeneca brand of bicalutamide; Zeneca brand of bicalutamide; Calutide (TN); Casodex (TN); Cosudex (TN); KS-1161; Kalumid (TN); Bicalutamide [USAN:INN:BAN]; Bicalutamide (JAN/USP/INN); Casodex, Cosudex, Calutide, Kalumid, Bicalutamide; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide; (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide; 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide Click to Show/Hide
Disease Class	2C82: Prostate cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C18H14F4N2O4S
InChI	1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey	LKJPYSCBVHEWIU-UHFFFAOYSA-N
Canonical SMILES	CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
External Link
	Pubchem ID	2375
	CAS Number	90357-06-5
	CHEBI ID	91617
	TTD ID	D0V9BD
	INTEDE ID	DR0210
	VARIDT ID	DR00795

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bicalutamide
Affected cellular transport
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Minor		Inter Info	[82]
D0481		Dicoumarol	C19H12O6	54676038	Minor		Inter Info	[469], [470], [82]
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[82]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 93
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[4], [38]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[39], [40]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[41]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[40]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[81], [4], [5], [82]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[4], [122], [123], [124], [50], [125], [126], [127], [128]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[81], [4], [5], [82]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[142], [143], [5], [133], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[165], [166]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [123], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [152], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[228], [152]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[4], [5], [259], [260], [261], [262], [263], [264]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[5], [276]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[5], [277]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [5], [282]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[283], [4], [5], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[283], [4], [5]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[5], [298]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[299], [300], [301], [302], [303], [304], [305], [306], [307]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[308]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[309], [4], [5], [310], [311], [312], [313], [314], [315]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[316]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[317]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[318]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[319], [320], [321]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[322], [152]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[323]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[324]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[165], [166]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[325]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[326], [327]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[329]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[330], [331]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[332]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [5], [333]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[334]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[335]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[4], [5], [336], [152]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[337]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[338]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[339], [340]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[341], [342], [4], [343], [344], [345], [346], [313]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[341], [342], [4]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[5], [351]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[354]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[355]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[356]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [360]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[5], [361]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[362]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[363]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[364]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[365]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[5], [133], [366]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[4], [367]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[368]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[369]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [370], [371]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[372]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[4], [5], [373]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[374]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[375]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[377]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[379], [152]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[380], [381], [382], [383], [384], [123], [385], [319], [386], [320], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [321], [397], [398], [399], [400]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[401]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[404]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[380], [381], [382], [383], [384], [123], [385], [319], [386], [320], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [321], [397], [398], [399], [400]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[405], [406], [407], [5], [123], [408], [409]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[411], [412]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[3], [4], [5], [413], [414], [415], [416]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[4], [5], [413]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[5], [417]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [123], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [152], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[319], [320], [321]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[3], [4], [5]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[440], [441], [442], [443], [444], [445], [446]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[447], [448], [449], [450]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [123], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [152], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[4], [5], [451], [452], [453], [152], [454]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4], [5], [451], [452], [453], [152], [454]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[455]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[459], [460]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[461], [152]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[4], [5], [462]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[464]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[465]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[466]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[467]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[5], [468]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[471], [472], [473], [474]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[478]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[479], [480], [481], [482], [483], [484], [485]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[44]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[49]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [77], [78]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [77], [78]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[265], [266], [267], [4], [5], [268], [269], [270], [271], [272], [273], [274], [275]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[281]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[265], [266], [267], [4], [5], [268], [269], [270], [271], [272], [273], [274], [275]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[5], [297]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[328]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[347], [348], [349], [350]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [5], [357], [358], [359]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[378]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[402], [403]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[347], [348], [349], [350]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [420]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[424]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[265], [266], [267], [4], [5], [268], [269], [270], [271], [272], [273], [274], [275]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[457], [458]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[4], [5], [164]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[4], [421], [1], [422], [423]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[4], [5], [164]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[428], [5], [429]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[5], [421], [1], [463]
	Increased risk of prolong QT interval					Drug Num: 147
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[3], [4], [5], [16]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[17]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[20]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[5], [21]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[3], [4], [5], [22]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[23]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[3], [4], [5], [24]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[27], [3], [4], [5], [28], [29], [30], [31], [32]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[3], [4], [5], [33], [15]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[36]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[37]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[4], [5], [42]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[43]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[3], [4], [5], [45]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[46]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[3], [4], [5], [48]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[3], [4], [5], [50], [51], [52], [53], [15]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[54], [55], [3], [4], [5], [56], [57]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[5], [58]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[60], [3], [4], [5], [61], [62], [63], [51], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[3], [4], [5], [79]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[3], [4], [5], [80]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[3], [4], [5], [83], [84], [15], [26]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [4], [5], [85], [15]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[3], [4], [5], [86]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[3], [4], [5], [87]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[3], [4], [5], [50], [88], [15]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[89], [60], [90], [3], [4], [5], [91], [92], [63], [93], [51], [94], [64], [66], [67], [95], [69], [70], [71], [72], [96], [97], [98], [74], [99], [100]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[60], [3], [4], [5], [101], [102], [75]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[3], [4], [5], [103], [104], [105], [106], [107], [108], [15]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[3], [4], [5], [109]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[3], [4], [5], [110], [15]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[3], [4], [5], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [15]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[3], [4], [5], [121]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[89], [60], [90], [3], [4], [5], [91], [92], [63], [93], [51], [94], [64], [66], [67], [95], [69], [70], [71], [72], [96], [97], [98], [74], [99], [100]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[3], [4], [5], [129], [50], [130], [131], [132], [15]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[3], [4], [5], [133]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[3], [4], [5], [50], [134], [15]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[5], [162], [163]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[5], [162], [163]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[5], [162], [163]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[5], [162], [163]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[5], [162], [163]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[5], [162], [163]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[4], [5], [410]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[418], [419]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [5], [425]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[426], [427]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[430], [431], [432], [433], [434], [435], [436], [437], [438], [439]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[5], [157], [158], [159], [160], [161], [162], [163]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[4], [475], [476], [477]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[3], [4], [5], [486], [487], [488], [489]
	Increased risk of ventricular arrhythmias					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[18], [19]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[3], [4], [5], [25], [26]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[5], [34], [35]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[47]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [59]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[3], [135], [4], [5], [136], [137], [138], [139], [140], [141]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[4], [5], [280]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[242], [252], [255]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[5], [352], [353]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[5], [352], [353]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[4], [5], [280]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[5], [352], [353]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[242], [252], [255]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[242], [252], [255]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[3], [4], [5], [278], [279], [280]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[242], [252], [255]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[242], [252], [255]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [456]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1756		Capromab pendetide	C10H15N5O11P2	135509147	Moderate		Inter Info	[376]

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246	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
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272	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
273	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
274	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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298	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
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316	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
317	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
318	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
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322	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
323	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
324	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
325	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
326	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
327	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
328	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
329	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
330	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
331	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
332	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
333	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
334	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
335	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
336	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
337	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
338	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
339	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
340	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
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344	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
345	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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347	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
348	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
349	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
350	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
351	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
352	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
353	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
354	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
355	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
356	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
357	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
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359	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
360	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
361	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
362	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
363	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
364	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
365	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
366	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
367	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
368	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
369	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
370	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
371	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
372	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
373	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
374	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
375	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
376	Product Information. ProstaScint (capromab pendetide). Aytu BioScience, Inc, Englewood, CO.
377	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
378	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
379	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
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393	Product Information. Cafergot (caffeine-ergotamine). Novartis Pharmaceuticals, East Hanover, NJ.
394	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
395	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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404	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
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408	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
409	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
410	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
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415	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
416	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
417	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
418	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
419	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
420	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
421	Multum Information Services, Inc. Expert Review Panel.
422	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
423	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
424	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
425	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
426	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
427	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
428	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
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440	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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444	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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448	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
449	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
450	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
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452	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
453	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
454	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
455	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
456	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
457	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
458	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
459	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
460	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
461	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
462	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
463	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
464	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
465	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
466	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
467	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
468	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
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472	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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476	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
477	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
478	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
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484	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
485	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
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