Drug General Information (ID: DDIYDME0W4)
Drug Name			Capromab pendetide		Drug Info		Bicalutamide		Drug Info
Drug Type		Monoclonal antibody				Small molecule
Therapeutic Class		Diagnostic Agents				Antineoplastics
Structure

Mechanism of Capromab pendetide-Bicalutamide Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Capromab pendetide				Bicalutamide
Mechanism		Indium In 111 capromab pendetide				Interfere with the imaging performance of Indium In 111 capromab pendetide due to the increased expression of PSMA
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Capromab pendetide when combined with Bicalutamide

Recommended Action
Management		Until more data are available, concomitant use of Indium In 111 capromab pendetide in patients treated with androgen ablation therapy is not recommended.

References
1	Product Information. ProstaScint (capromab pendetide). Aytu BioScience, Inc, Englewood, CO.