Drug General Information (ID: DDIVTODCEX)
Drug Name			Dicoumarol		Drug Info		Bicalutamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticoagulants				Antineoplastics
Structure

Mechanism of Dicoumarol-Bicalutamide Interaction (Severity Level: Minor)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Dicoumarol				Bicalutamide
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Bicalutamide and Dicoumarol due to competitive binding of plasma proteins

References
1	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
2	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
3	Product Information. Casodex (bicalutamide). Zeneca Pharmaceuticals, Wilmington, DE.