Details of Drug

Drug General Information (ID: D0175)
Drug Name	Bethanechol
Drug Type	Small molecule
Drug Synonymous	Amidopropyldimethylbetaine; Bethanecol; Urabeth; Myotonine chloride; Duvoid (TN); Myotonachol (TN); Urecholine (TN); Carbamoyl-beta-methylcholine; Carbamyl-beta-methylcholine; Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester); (2-Hydroxypropyl)trimethylammonium carbamate; 1-Propanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-(9CI); 2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propanaminium; 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium; 2-carbamoyloxypropyl(trimethyl)azanium; 2-carbamoyloxypropyl-trimethylazanium Click to Show/Hide
Disease Class	MF50: Abnormal micturition
Therapeutic Class	Parasympathomimetics
Structure
Structure	3D Structure		2D Structure
Formula	C7H17N2O2+
InChI	1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1
InChIKey	NZUPCNDJBJXXRF-UHFFFAOYSA-O
Canonical SMILES	CC(C[N+](C)(C)C)OC(=O)N
External Link
	Pubchem ID	2370
	CAS Number	674-38-4
	CHEBI ID	3084
	TTD ID	D07ZTO

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM037 Additive cholinergic effects BM069 Increased risk of lowers seizure threshold BM091 Antagonize the effect of cholinergic agents
Relation Graph

Full list of drugs interacting with Bethanechol
Pharmacodynamic additive effects
	Additive cholinergic effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[25], [26]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[35], [36], [37]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[35], [36], [37]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[35], [36], [37]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[35], [36], [37]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[35], [36], [37]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[35], [36], [37]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[35], [36], [37]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[35], [36], [37]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[16], [17], [18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[16], [17], [18], [19], [20]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[21], [14], [13], [22]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[38], [39], [40]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[38], [39], [40]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[38], [39], [40]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[41], [40]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[42], [43], [44]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[23], [24]
D0124		Atropine (ophthalmic)	C17H23NO3	174174	Moderate		Inter Info	[23], [24]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[23], [24]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[23], [24]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[23], [24]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[23], [24]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[23], [24]
D0759		Homatropine	C16H21NO3	5282593	Moderate		Inter Info	[23], [24]
D0760		Homatropine (ophthalmic)	C16H21NO3	5282593	Moderate		Inter Info	[23], [24]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[23], [24]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[23], [24]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[23], [24]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[23], [24]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[23], [24]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[23], [24]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[23], [24]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[23], [24]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[23], [24]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[23], [24]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[23], [24]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[23], [24]
D0399		Cyclopentolate (ophthalmic)	C17H25NO3	2905	Moderate		Inter Info	[23], [24]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[23], [24]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[23], [24]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[23], [24]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[23], [24]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[23], [24]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[23], [24]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[23], [24]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[23], [24]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[23], [24]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[23], [24]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[23], [24]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[23], [24]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[23], [24]
D1451		Scopolamine (ophthalmic)	C17H21NO4	3000322	Moderate		Inter Info	[23], [24]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[23], [24]
D1655		Tropicamide (ophthalmic)	C17H20N2O2	5593	Moderate		Inter Info	[23], [24]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[23], [24]

References
1	Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
2	Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]
3	Canadian Pharmacists Association.
4	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
5	Gittelman DK, Kirby MG "A seizure following bupropion overdose." J Clin Psychiatry 54 (1993): 162. [PMID: 8486598]
6	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
7	James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
8	Masco HL, Kiev A, Holloman LC, Batey SR, Johnston JA, Lineberry CG "Safety and efficacy of bupropion and nortriptyline in outpatients with depression." Curr Ther Res Clin Exp 55 (1994): 851-63.
9	Dufresne RL, Weber SS, Becker RE "Bupropion hydrochloride." Drug Intell Clin Pharm 18 (1984): 957-64. [PMID: 6439541]
10	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
11	Storrow AB "Bupropion overdose and seizure." Am J Emerg Med 12 (1994): 183-4. [PMID: 8161393]
12	Johnston JA, Lineberry CG, Ascher JA, et al. "A 102-center prospective study of seizure in association with bupropion." J Clin Psychiatry 52 (1991): 450-6. [PMID: 1744061]
13	Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
14	Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
15	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
16	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
17	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
18	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
19	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
20	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
21	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
22	Gardiner JS, Blough D, Drinkard CR, et al. "Tramadol and seizures: a surveillance study in a managed care population." Pharmacotherapy 20 (2000): 1423-31. [PMID: 11130214]
23	Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
24	Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
25	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
26	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
27	Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
28	Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
29	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
30	Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
31	Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
32	Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
33	Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
34	Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
35	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
36	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
37	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
38	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
39	Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
40	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
41	Cerner Multum, Inc. "Australian Product Information.".
42	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
43	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
44	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.

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