Details of Drug

Details of Drug

 Drug General Information (ID: D0148)
  Drug Name
Beclomethasone dipropionate
  Drug Type Small molecule
  Drug Synonymous
BECLOMETHASONE DIPROPIONATE; Beclometasone dipropionate; 5534-09-8; Beclovent; Beconase; Vancenase; Beclazone; Becloforte; Beclomet; Beclorhinol; Propaderm; Sanasthmax; Sanasthmyl; Vanceril; Aerobec; Aldecin; Beclacin; Entyderma; Korbutone; Viarox; Rino-clenil; Clenil-A; Beclometasone 17,21-dipropionate; Becotide; Qvar; QNASL; Beconase AQ; SCH 18020W; Beclate; Becodisks; Benconase; Propaderm Forte; CHEBI:3002; (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Inalone O; Inalone R; UNII-5B307S63B2; 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; 9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; 5B307S63B2; Becloturmant; Respocort; Anceron; Becloval; [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate; Viarex; Alanase; Aldecina; Aldecine; Atomase; Rhinosol; Turbinal; Ventolair; Clenil; Spir; Beclocort Nasel; Beclomet Nasal; Rhino Clenil; (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate; 9-chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate; Qvar 80; Vanceril Double Strength; Beconasol; Inalone; Menaderm; QVAR 40; MFCD00135613; NSC-755901; Beclovent (TN); NCGC00094596-03; Vanceril (TN); Beclazone 250; Prestwick_990; EINECS 226-886-0; KW-053; Qnasl (TN); Beclometasone dipropionato; Prestwick0_000855; Prestwick1_000855; Prestwick2_000855; Prestwick3_000855; beclomethasone-dipropionate; SCHEMBL6890; DSSTox_CID_28656; DSSTox_RID_82926; Propionic acid beclomethasone; DSSTox_GSID_48730; BSPBio_000869; MLS002154034; SPBio_002790; BPBio1_000957; GTPL5894; CHEMBL1200500; DTXSID3048730; SCH 8020W; SGX-201; SGX-202; SGX-203; Beclomethasone dipropionate (USP); HMS1570L11; HMS2097L11; HMS2235O23; HMS3259H03; HMS3714L11; Beclometasone dipropionate (JP17); 9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; beclomethasone dipropionate anhydrous; Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11.beta.,16.beta.)-; ZINC3938744; Tox21_113168; HY-13571A; s3078; AKOS015951275; AC-2159; CCG-220855; CS-1503; DB00394; NC00610; NSC 755901; Beclomethasone dipropionate [USAN:USP]; NCGC00179392-01; (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate; CPD001233361; Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)-; Pregna-1,4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-, 17,21-dipropionate; SMR001233361; CAS-5534-09-8; B4464; C07813; D00689; D89082; 534B098; Q421475; BRD-K97810537-001-03-7; BRD-K97810537-001-13-6; Beclomethasone dipropionate, analytical standard, for drug analysis; Beclometasone (beclomethasone) dipropionate, British Pharmacopoeia (BP) Assay Standard; Beclomethasone dipropionate, anhydrous, European Pharmacopoeia (EP) Reference Standard; Beclomethasone Dipropionate, Pharmaceutical Secondary Standard; Certified Reference Material; Beclomethasone dipropionate, United States Pharmacopeia (USP) Reference Standard; [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate; 2-[(1R,2S,10S,11S,13S,14R,15S,17S)-1-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate; 9alpha-chloro-16beta-methyl-3,20-dioxo-1,4-pregnadiene-11beta,17,21-triol 17,21-dipropionate; Beclometasone dipropionate for peak identification, European Pharmacopoeia (EP) Reference Standard; Beclometasone dipropionate for system suitability, European Pharmacopoeia (EP) Reference Standard
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  Therapeutic Class Inhaled Corticosteroids
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C28H37ClO7
  InChI InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
  InChIKey KUVIULQEHSCUHY-XYWKZLDCSA-N
  Canonical SMILES CCC(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)OC(=O)CC
  External Link
Pubchem ID 21700
INTEDE ID DR0180
VARIDT ID DR01665

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM043  Additive immunosuppressive effects
BM065  Increased risk of hypokalemia
BM067  Increased risk of hyponatremia
BM092  Antagonize the effect of corticosteroids
  Relation Graph
 Full list of drugs interacting with Beclomethasone dipropionate
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[13], [14], [15]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[11]
      Affected intra/extra-hepatic metabolism
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0203
 
Brexucabtagene autoleucel
 
NA
 
NA
Major    Inter Info   
[1]
D0501
 
Dinutuximab
 
NA
 
NA
Major    Inter Info   
[1]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Major    Inter Info   
[4]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[12]
   Increased risk of hypokalemia Drug Num:  40
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0012
 
Acetazolamide
 
C4H6N4O3S2
 
1986 
Moderate    Inter Info   
[8], [9], [10]
D0075
 
Amphotericin B
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[8], [9], [10]
D0076
 
Amphotericin B (cholesteryl sulfate)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[8], [9], [10]
D0077
 
Amphotericin B (lipid complex)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[8], [9], [10]
D0078
 
Amphotericin B (liposomal)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[8], [9], [10]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[8], [9], [10]
D0166
 
Benzthiazide
 
C15H14ClN3O4S3
 
2343 
Moderate    Inter Info   
[8], [9], [10]
D0217
 
Bumetanide
 
C17H20N2O5S
 
2471 
Moderate    Inter Info   
[8], [9], [10]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[8], [9], [10]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[8], [9], [10]
D0479
 
Diclofenamide
 
C6H6Cl2N2O4S2
 
3038 
Moderate    Inter Info   
[8], [9], [10]
D0613
 
Etacrynic acid
 
C13H12Cl2O4
 
3278 
Moderate    Inter Info   
[8], [9], [10]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Moderate    Inter Info   
[8], [9], [10]
D0704
 
Furosemide
 
C12H11ClN2O5S
 
3440 
Moderate    Inter Info   
[8], [9], [10]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[8], [9], [10]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[8], [9], [10]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[8], [9], [10]
D1018
 
Methazolamide
 
C5H8N4O3S2
 
4100 
Moderate    Inter Info   
[8], [9], [10]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[8], [9], [10]
D1231
 
Patiromer
 
NA
 
NA
Moderate    Inter Info   
[8], [9], [10]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[8], [9], [10]
D1605
 
Tolevamer
 
C11H16O3S
 
58817179 
Moderate    Inter Info   
[8], [9], [10]
D1633
 
Trichlormethiazide
 
C8H8Cl3N3O4S2
 
5560 
Moderate    Inter Info   
[8], [9], [10]
D0252
 
Capreomycin
 
C50H88N28O15
 
3000502 
Moderate    Inter Info   
[8], [9], [10]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[8], [9], [10]
D1611
 
Torasemide
 
C16H20N4O3S
 
41781 
Moderate    Inter Info   
[8], [9], [10]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Minor    Inter Info   
[7], [1], [16]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Minor    Inter Info   
[7], [1], [16]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Minor    Inter Info   
[7], [1], [16]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Minor    Inter Info   
[7], [1], [16]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Minor    Inter Info   
[7], [1], [16]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Minor    Inter Info   
[7], [1], [16]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Minor    Inter Info   
[7], [1], [16]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Minor    Inter Info   
[7], [1], [16]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Minor    Inter Info   
[7], [1], [16]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Minor    Inter Info   
[7], [1], [16]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Minor    Inter Info   
[7], [1], [16]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Minor    Inter Info   
[7], [1], [16]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Minor    Inter Info   
[7], [1], [16]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Minor    Inter Info   
[7], [1], [16]
   Increased risk of hyponatremia Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0449
 
Desmopressin
 
C46H64N14O12S2
 
5311065 
Major    Inter Info   
[5], [6], [7]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of corticosteroids Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[2], [3]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
3 Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
4 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
5 Product Information. Nocdurna (desmopressin). Ferring Inc, North York, ON.
6 Product Information. Stimate (desmopressin). Forest Pharmaceuticals, St. Louis, MO.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Morris GC, Egan JG, Jones MK "Hypokalaemic paralysis induced by bolus prednisolone in Graves' disease." Aust N Z J Med 22 (1992): 312. [PMID: 1497563]
9 Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5. [PMID: 6698408]
10 Product Information. Hydeltrasol (prednisolone). Merck &amp Co, Inc, West Point, PA.
11 Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
12 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
13 Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
14 Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
15 Product Information. EXUBERA (insulin inhalation, rapid acting). Pfizer U.S. Pharmaceuticals Group, New York, NY.
16 Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.