Drug General Information (ID: DDIPEZOKM2)
Drug Name			Beclomethasone dipropionate		Drug Info		Brexucabtagene autoleucel		Drug Info
Drug Type		Small molecule				Autologous cell transplant
Therapeutic Class		Inhaled Corticosteroids				Antineoplastics

Mechanism of Beclomethasone dipropionate-Brexucabtagene autoleucel Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Beclomethasone dipropionate				Brexucabtagene autoleucel
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Beclomethasone dipropionate and Brexucabtagene autoleucel

Recommended Action
Management		The prophylactic use of systemic corticosteroids prior to the administration of brexucabtagene autoleucel is not recommended. However, systemic corticosteroids may be used for the management of brexucabtagene autoleucel-related adverse effects, such as cytokine release syndrome and neurological-related toxicities, without affecting the expansion and persistence of cells.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".