Details of Drug

Details of Drug

 Drug General Information (ID: D0081)
  Drug Name
Amprenavir (oral solution)
  Drug Type Small molecule
  Drug Synonymous
AMV; Agenerase; Amprenavir[usan]; Prozei; Vertex; Amprenavir [USAN]; VX 478; VX478; Vertex VX478; Agenerase (TM); Agenerase (TN); DRG-0258; GNA & Amprenavir; HHA & Amprenavir; KVX-478; VX-478; Amprenavir (JAN/USAN/INN); Tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER; [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Galanthus nivalis agglutinin (GNA); Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Hippeastrum hybrid agglutinin(HHA); (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate; (3S)-Tetrahydro-3-furyl ((alphaS)-alpha-((1R-1-hydroxy-2-(N(sup 1)-isobutylsulfanilamido)ethyl)phenethyl)carbamate; (3S)-tetrahydro-3-furyl N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxy-propyl]carbamate; (3S-(3R*(1R*,2S*)))-(3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl) tetrahydro-3-furanyl carbamate; 4-Amino-N-((2 syn,3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutyl-benzenesulfonamide
    Click to Show/Hide
  Disease Class 1C60-1C62: Human immunodeficiency virus disease
  Therapeutic Class Anti-Hiv Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C25H35N3O6S
  InChI 1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1
  InChIKey YMARZQAQMVYCKC-OEMFJLHTSA-N
  Canonical SMILES CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N
  External Link
Pubchem ID 65016
CAS Number 161814-49-9
CHEBI ID 40050
TTD ID D0A0OO
INTEDE ID DR0107
VARIDT ID DR00584

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
BM018  Non-CYP450 enzyme inhibition
  Relation Graph
 Full list of drugs interacting with Amprenavir (oral solution)
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0162
 
Benznidazole
 
C12H12N4O3
 
31593 
Major    Inter Info   
[1], [2], [3]
D0509
 
Disulfiram
 
C10H20N2S4
 
3117 
Major    Inter Info   
[1], [4], [2], [3]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Major    Inter Info   
[1], [4], [2], [3]
D1052
 
Metronidazole (topical)
 
C6H9N3O3
 
4173 
Major    Inter Info   
[1], [2], [3]
D1587
 
Tinidazole
 
C8H13N3O4S
 
5479 
Major    Inter Info   
[1], [4], [2], [3]
References
1 Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
2 Product Information. Metrogel-Vaginal (metronidazole). Curatek Pharmaceuticals Ltd, Elk Grove Village, IL.
3 Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
4 Product Information. Flagyl (metronidazole). Searle, Skokie, IL.