Details of Drug

Drug General Information (ID: D0053)
Drug Name	Ambrisentan
Drug Type	Small molecule
Drug Synonymous	Letairis; Ambrisentan [INN]; Gilead brand of ambrisentan; BSF 208075; BSF208075; LU 208075; LU208075; BSF-208075; LU-208075; Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid; 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Agents For Pulmonary Hypertension
Structure
Structure	3D Structure		2D Structure
Formula	C22H22N2O4
InChI	1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey	OUJTZYPIHDYQMC-LJQANCHMSA-N
Canonical SMILES	CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
External Link
	Pubchem ID	6918493
	CAS Number	177036-94-1
	CHEBI ID	135949
	TTD ID	D0X5ZI
	INTEDE ID	DR0080
	VARIDT ID	DR00311

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM042 Additive hypotensive effects BM055 Increased risk of hepatotoxicity BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ambrisentan
Affected cellular transport
	Transporter inhibition					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[6], [7], [8]
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[26], [27]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[11], [29], [30]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[32]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[11], [34]
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[35], [36], [37]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[16], [38]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[11], [39]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[16], [11], [40]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[43]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[46]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[11], [47]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[11]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[50]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[8]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[8]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[45]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[49]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[51], [52], [53]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[54]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[74], [75]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[76]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[84]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[8]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[8]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[8]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[8]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[8]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[8]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[8]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[8]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[8]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[8]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[8]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[8]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[8]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[8]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[8]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[8]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[8]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[8]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[8]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[8]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[8]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[8]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[8]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[8]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[8]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[8]
	UGT inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[11], [85], [86]
	CYP450 enzyme induction					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[11], [12]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[11], [33]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[41], [16], [11], [42]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[44]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[58]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[77]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[93], [94], [95], [96], [97]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[93], [94], [95], [96], [97]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[10]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[16], [11], [31]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[16], [11], [31]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[59], [60], [61]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[66]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[67], [68], [69]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[70], [71], [72]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[67], [68], [69]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[67], [68], [69]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[16], [11], [31]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[11], [79], [53]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[81], [82]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[87]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[70], [71], [72]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[70], [71], [72]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[98], [99]
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[2]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [4], [5]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [4], [5]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[9]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [11], [17], [18], [19], [20], [21], [22], [23], [24]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[25]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[28]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [11], [17], [18], [19], [20], [21], [22], [23], [24]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[48]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [11], [17], [18], [19], [20], [21], [22], [23], [24]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[73]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[16], [11], [78]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [80]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[83]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[88], [89]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [90]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[55], [56], [57]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[91], [92]

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98	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
99	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

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