Details of Drug

Drug General Information (ID: D0044)
Drug Name	Alpelisib
Drug Type	Small molecule
Drug Synonymous	alpelisib; 1217486-61-7; BYL-719; BYL719; UNII-08W5N2C97Q; BYL 719; Alpelisib (BYL719); (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; NVP-BYL719; (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide; CHEMBL2396661; 08W5N2C97Q; AK146107; C19H22F3N5O2S; (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer; 2C60-2C6Y: Breast cancer
Therapeutic Class	Pi3K Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C19H22F3N5O2S
InChI	1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
InChIKey	STUWGJZDJHPWGZ-LBPRGKRZSA-N
Canonical SMILES	CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
External Link
	Pubchem ID	56649450
	CAS Number	1217486-61-7
	CHEBI ID	93752
	TTD ID	D0W7HE
	INTEDE ID	DR0074

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Alpelisib
Affected cellular transport
	Transporter inhibition					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[2], [3], [4], [5]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[10], [2], [11], [12]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[13]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[14], [15]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[14], [2], [16]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2], [20], [1]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[21]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[2], [20], [1]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[2], [20], [1]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[22]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[14], [23]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[24]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[2], [20], [1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[2], [20], [1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[2], [25]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[26], [27]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[2], [20], [1]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[2], [20], [1]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[2], [20], [1]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[28], [29], [30], [31]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[28], [30], [31]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[2], [20], [1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[2], [20], [1]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[2], [20], [1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2], [20], [1]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[2], [20], [1]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[2], [20], [1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[2], [20], [1]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2], [20], [1]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[2], [20], [1]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[2], [20], [1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[2], [20], [1]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[2], [20], [1]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[32]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[28], [29], [30], [31]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2], [20], [1]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[2], [20], [1]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[2], [20], [1]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[2], [20], [1]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[2], [20], [1]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[2], [20], [1]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[34]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[2], [20], [1]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [20], [1]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[2], [20], [1]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [20], [1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[37]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[2], [20], [1]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[2], [20], [1]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[2], [20], [1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2], [20], [1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[2], [20], [1]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[2], [20], [1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[38]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[2], [20], [1]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[2], [20], [1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[2], [20], [1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[39]
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[2], [20], [1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[2], [20], [1]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[2], [20], [1]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[2], [20], [1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[2], [20], [1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[2], [20], [1]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[40]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[2], [20], [1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[2], [20], [1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[41]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[2], [20], [1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[2], [20], [1]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[2], [20], [1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[2], [20], [1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[2], [20], [1]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[2], [20], [1]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[42]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[43]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[6]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[17], [18], [19]
	CYP450 enzyme induction					Drug Num: 114
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[1]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[1]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[2], [1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[1]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[1]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[1]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[2], [1]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[1]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[1]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[1]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[1]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[2], [1]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[1]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[2], [1]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[1]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[1]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[1]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[2], [1]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[1]
D0994		Melatonin	C13H16N2O2	896	Moderate		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[1]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[35], [36], [1]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[35], [36], [1]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[1]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1133		Nicotine	C10H14N2	89594	Moderate		Inter Info	[2], [1]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[1]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[2], [1]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[1]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[35], [36], [1]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[2], [1]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[1]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[35], [36], [1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[1]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[35], [36], [1]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[35], [36], [1]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[35], [36], [1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[35], [36], [1]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[2], [1]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[2], [1]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[2], [1]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[2], [1]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[33]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[2], [1]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[2], [1]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[2], [1]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[2], [1]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[7], [8], [9]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[7], [8], [9]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[7], [8], [9]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[7], [8], [9]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[7], [8], [9]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[7], [8], [9]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[7], [8], [9]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[7], [8], [9]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[7], [8], [9]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[7], [8], [9]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[7], [8], [9]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[7], [8], [9]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[7], [8], [9]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[7], [8], [9]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[7], [8], [9]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[7], [8], [9]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[7], [8], [9]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[7], [8], [9]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[7], [8], [9]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[7], [8], [9]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[7], [8], [9]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[7], [8], [9]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[7], [8], [9]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[7], [8], [9]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[7], [8], [9]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[7], [8], [9]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[7], [8], [9]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[7], [8], [9]

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