Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDINU14H0K)
  Drug Name Meropenem Drug Info Alpelisib Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antibiotics Pi3K Inhibitors
  Structure

 Mechanism of Meropenem-Alpelisib Interaction (Severity Level: Moderate)
     Transporter inhibition Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Meropenem Alpelisib
      Mechanism OAT3 substrate OAT3 inhibitor
      Key Mechanism Factor 1
Factor Name Solute carrier family 22 member 8
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Structure Sequence
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
Gene Name OAT3
Uniprot ID S22A8_HUMAN
KEGG Pathway hsa:9376
Protein Family Major facilitator (TC 2.A.1) superfamily
Protein Function
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
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      Mechanism Description
  • Decreased clearance of Meropenem due to the transporter inhibition by Alpelisib 

Recommended Action
      Management Caution is advised if alpelisib must be used concomitantly with drugs that are substrates of the affected transporters, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever alpelisib is added to or withdrawn from therapy.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
3 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.