Drug General Information (ID: DDIZU7WSHX)
Drug Name			Azelaic acid (topical)		Drug Info		Isotretinoin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dermatologic Agents				Antiacne Agents/Antineoplastics
Structure

Mechanism of Azelaic acid (topical)-Isotretinoin Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Azelaic acid (topical)				Isotretinoin
Mechanism		Local skin irritation/drying				Local skin irritation/drying
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Azelaic acid (topical) and Isotretinoin

Recommended Action
Management		Concurrent use should generally be avoided.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".