Drug General Information (ID: DDIZT9F8CG)
Drug Name			Mecamylamine		Drug Info		Licorice		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antihypertensive Agents				Herbal Products
Structure

Mechanism of Mecamylamine-Licorice Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Mecamylamine				Licorice
Mechanism		Hypotensive effects Neuronal acetylcholine receptor  Antagonist				Hypertensive effects Mineralocorticoid and renin-suppressing effects
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Mecamylamine when combined with Licorice

Recommended Action
Management		Patients receiving antihypertensive therapy should avoid or limit the consumption of licorice-containing products. Even relatively moderate doses of licorice may be problematic in susceptible patients when ingested regularly for prolonged periods.

References
1	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
2	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
3	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90