Drug General Information (ID: DDIZSTG8YW)
Drug Name			Lovastatin		Drug Info		Lenalidomide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Statins/Antihyperlipidemic Agents				Antineoplastics
Structure

Mechanism of Lovastatin-Lenalidomide Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Lovastatin				Lenalidomide
Mechanism		Rhabdomyolysis				Rhabdomyolysis
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Lovastatin and Lenalidomide

Recommended Action
Management		European product labeling recommends caution and increased clinical and biological monitoring if lenalidomide is used in combination with statins, especially during the first several weeks of treatment. All patients treated with statins should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
3	EMA. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) "Revlimid."