Drug General Information (ID: DDIZQL8ID0)
  Drug Name Sucralfate Drug Info Diclofenac Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Gi Agents Nsaids/Analgesics
  Structure

 Mechanism of Sucralfate-Diclofenac Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Sucralfate Diclofenac
      Mechanism Decrease absorption of diclofenac Diclofenac
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Diclofenac caused by Sucralfate 

References
1 Pedrazzoli Junior J, Pierossi M de A, Muscara MN, Dias HF, da Silva CM, Mendes FD, de Nucci G "Short-term sucralfate administration alters potassium diclofenac absorption in healthy male volunteers." Br J Clin Pharmacol 43 (1997): 104-8. [PMID: 9056060]