Drug General Information (ID: DDIZOHFBN3)
  Drug Name Nizatidine Drug Info Mecobalamin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiulcer Agents Vitamins
  Structure

 Mechanism of Nizatidine-Mecobalamin Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nizatidine Mecobalamin
      Mechanism Gastric alkalinizer Gastric pH sensitive
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Mecobalamin due to altered gastric pH caused by Nizatidine 

References
1 Dutta SK "Vitamin b-12 malabsorption and omeprazole therapy." J Am Coll Nutr 13 (1994): 544-5. [PMID: 7706583]
2 Lavy NW "Omeprazole and vitamin B12." Ann Intern Med 121 (1994): 74. [PMID: 8198354]
3 Salom IL, Silvis SE, Doscherholmen A "Effect of cimetidine on the absorption of vitamin B12." Scand J Gastroenterol 17 (1982): 129-31. [PMID: 7134827]