Details of Drug

Drug General Information (ID: D0989)
Drug Name	Mecobalamin
Drug Type	Small molecule
Drug Synonymous	Methycobal; Methycobal S; E-0302 Click to Show/Hide
Disease Class	3A00-3A9Z: Anemia
Therapeutic Class	Vitamins
Structure
Structure	3D Structure		2D Structure
Formula	C63H91CoN13O14P
InChI	1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2/t31?,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
InChIKey	ZFLASALABLFSNM-WYVZQNDMSA-L
Canonical SMILES	[CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
External Link
	Pubchem ID	10898559
	CAS Number	13422-55-4
	TTD ID	D09ZHZ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM005 Altered gastric pH BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Mecobalamin
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[7], [8], [9]
D0603		Esomeprazole	C17H19N3O3S	9568614	Minor		Inter Info	[7], [8], [9]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[7], [8], [9]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Minor		Inter Info	[7], [8], [9]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Minor		Inter Info	[7], [8], [9]
D1151		Nizatidine	C12H21N5O2S2	3033637	Minor		Inter Info	[7], [8], [9]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[7], [8], [9]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Minor		Inter Info	[7], [8], [9]
D1373		Rabeprazole	C18H21N3O3S	5029	Minor		Inter Info	[7], [8], [9]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[7], [8], [9]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Minor		Inter Info	[7], [8], [9]
Pharmacodynamic additive effects
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Moderate		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [5], [6]

References
1	Product Information. Hydro-Cobex (hydroxocobalamin). Major Pharmaceuticals Inc, Rosemont, IL.
2	Product Information. Nascobol (cyanocobalamin nasal). Schwarz Pharma, Mequon, WI.
3	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
4	Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
5	Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
6	Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
7	Dutta SK "Vitamin b-12 malabsorption and omeprazole therapy." J Am Coll Nutr 13 (1994): 544-5. [PMID: 7706583]
8	Lavy NW "Omeprazole and vitamin B12." Ann Intern Med 121 (1994): 74. [PMID: 8198354]
9	Salom IL, Silvis SE, Doscherholmen A "Effect of cimetidine on the absorption of vitamin B12." Scand J Gastroenterol 17 (1982): 129-31. [PMID: 7134827]