| Mechanism of Darifenacin-Nitroglycerin Interaction
(Severity Level: Minor)
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Affecting drug dissolution
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| Drug Name |
Darifenacin |
Nitroglycerin |
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Mechanism
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Decrease the dissolution of sublingual nitroglycerin |
Nitroglycerin |
| Key Mechanism Factor 1 |
| Factor Name |
Salivary gland |
| Factor Description |
Sublingual administration requires the drug to be dissolved by saliva and then absorbed from the oral mucosa. The absorption of the drug may be decreased when saliva production is reduced. |
| Mechanism Description |
- Decreased dissolution of Nitroglycerin taken sublingually caused by Darifenacin
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