Drug General Information (ID: DDIYZ4TRU1)
  Drug Name Mefenamic acid Drug Info Magnesium hydroxide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinflammatory Agents Antacids/Laxatives
  Structure

 Mechanism of Mefenamic acid-Magnesium hydroxide Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Mefenamic acid Magnesium hydroxide
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Mefenamic acid due to altered gastric pH caused by Magnesium hydroxide 

References
1 Neuvonen PJ, Kivisto KT "Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids." Eur J Clin Pharmacol 35 (1988): 495-501. [PMID: 3266151]