Drug General Information (ID: DDIY4QKX2R)
Drug Name			Efavirenz		Drug Info		Dasabuvir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antiviral Agents
Structure

Mechanism of Efavirenz-Dasabuvir Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Efavirenz				Dasabuvir
Mechanism		Reduce tolerance and elevate liver enzymes in combination with dasabuvir				Dasabuvir
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Dasabuvir when combined with Efavirenz

Recommended Action
Management		Concomitant use of efavirenz with ombitasvir/paritaprevir/ritonavir plus dasabuvir is considered contraindicated.

References
1	Aarnoutse RE, Grintjes KJ, Telgt DS, et al. "The influence of efavirenz on the pharmacokinetics of a twice-daily combination of indinavir and low-dose ritonavir in healthy volunteers." Clin Pharmacol Ther 71 (2002): 57-67. [PMID: 11823758]
2	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
3	Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir). AbbVie US LLC, North Chicago, IL.