Details of Drug

Details of Drug

 Drug General Information (ID: D0427)
  Drug Name
Dasabuvir
  Drug Type Small molecule
  Drug Synonymous
Dasabuvir; 1132935-63-7; ABT-333; N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; ABT333; UNII-DE54EQW8T1; ABT 333; Dasabuvir (ABT-333); DE54EQW8T1; CHEBI:85182; N-(6-(3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; C26H27N3O5S; Dasabuvir [INN]; N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide; Dasabuvir [USAN:INN]; Dasabuvir (USA
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  Disease Class 1E50-1E51: Hepatitis virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C26H27N3O5S
  InChI 1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
  InChIKey NBRBXGKOEOGLOI-UHFFFAOYSA-N
  Canonical SMILES CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
  External Link
Pubchem ID 56640146
CAS Number 1132935-63-7
CHEBI ID 85182
TTD ID D04KJT
INTEDE ID DR0422
VARIDT ID DR01289

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM017  CYP450 enzyme inhibition
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Dasabuvir
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0715
 
Gemfibrozil
 
C15H22O3
 
3463 
Major    Inter Info   
[4], [3], [5]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[6], [3], [7]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[1], [2], [3]
References
1 Aarnoutse RE, Grintjes KJ, Telgt DS, et al. "The influence of efavirenz on the pharmacokinetics of a twice-daily combination of indinavir and low-dose ritonavir in healthy volunteers." Clin Pharmacol Ther 71 (2002): 57-67. [PMID: 11823758]
2 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
3 Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir). AbbVie US LLC, North Chicago, IL.
4 Ogilvie BW, Zhang D, Li W, et al. "Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions." Drug Metab Dispos 34 (2006): 191-7. [PMID: 16299161]
5 Tornio A, Filppula A, Kailari O, et al. "Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as perpetrator of drug-drug interactions." Clin Pharmacol Ther 96 (2014): 498-507. [PMID: 24971633]
6 Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
7 Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.