Drug General Information (ID: DDIXO4DYU9)
Drug Name			Fosamprenavir		Drug Info		Dexlansoprazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Proton Pump Inhibitors
Structure

Mechanism of Fosamprenavir-Dexlansoprazole Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Fosamprenavir				Dexlansoprazole
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Fosamprenavir due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		Caution is advised if fosamprenavir is prescribed with H2-receptor antagonists or proton pump inhibitors. Antiretroviral response should be monitored closely during coadministration.

References
1	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.