Drug General Information (ID: DDIXKH0WQE)
Drug Name			Terfenadine		Drug Info		Zileuton		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihistamines				Antiinflammatory Agents
Structure

Mechanism of Terfenadine-Zileuton Interaction (Severity Level: Major)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Terfenadine				Zileuton
Mechanism		Terfenadine				Decrease the clearance of terfenadine
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Terfenadine caused by Zileuton

Recommended Action
Management		The manufacturer recommends that these drugs not be coadministered due the high inter-individual variability of terfenadine pharmacokinetics.

References
1	Awni WM, Cavanaugh JH, Leese P, Kasier J, Cao GL, Locke CS, Dube LM "The pharmacokinetic and pharmacodynamic interaction between zileuton and terfenadine." Eur J Clin Pharmacol 52 (1997): 49-54. [PMID: 9143867]
2	Product Information. Zylo Filmtab (zileuton). Abbott Pharmaceutical, Abbott Park, IL.