Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIX9CVBEI)
  Drug Name Desmopressin Drug Info Tolvaptan Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiuretic Hormones Vasopressin Antagonists
  Structure

 Mechanism of Desmopressin-Tolvaptan Interaction (Severity Level: Moderate)
     Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Desmopressin Tolvaptan
      Mechanism Vasopressin V2 receptor agonist Vasopressin V2 receptor antagonist
      Key Mechanism Factor 1
Factor Name Vasopressin V2 receptor
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Structure Sequence
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Gene Name AVPR2 ADHR DIR DIR3 V2R
Uniprot ID V2R_HUMAN
KEGG Pathway hsa:554
Protein Family G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
Protein Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
    Click to Show/Hide
      Mechanism Description
  • Attenuated pharmacological effects of  Desmopressin when combined with Tolvaptan 

Recommended Action
      Management Concomitant use of tolvaptan with a V2-receptor agonist such as desmopressin is not recommended.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3 Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.