Details of Drug

Drug General Information (ID: D1608)
Drug Name	Tolvaptan
Drug Type	Small molecule
Drug Synonymous	Samsca; OPC 41061; Benzazepine derivative, 32; OPC-41061; Samsca (TN); N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; (-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide; 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine Click to Show/Hide
Disease Class	5C72: Hypo-osmolality/hyponatraemia; BD10-BD1Z: Heart failure
Therapeutic Class	Vasopressin Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C26H25ClN2O3
InChI	1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChIKey	GYHCTFXIZSNGJT-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
External Link
	Pubchem ID	216237
	CAS Number	150683-30-0
	CHEBI ID	32246
	TTD ID	D03KZM
	INTEDE ID	DR1617
	VARIDT ID	DR00059

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia BM082 Increased risk of hypernatremia BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tolvaptan
Affected cellular transport
	Transporter inhibition					Drug Num: 80
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[11]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[2]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[2]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[1], [5], [27], [2]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[2]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[28], [29], [30], [31]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[28], [30], [31]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[1], [5], [27], [2]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [5], [27], [2]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1], [5], [27]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [5], [27], [2]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[1], [5], [27], [2]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1], [5], [27], [2]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[1], [5], [27], [2]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[2]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[28], [29], [30], [31]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[2]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1], [5], [27], [2]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[2]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[1], [5], [27], [2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[1], [5], [27]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[2]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[2]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[2]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[2]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[1], [5], [27], [2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[43]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[1], [5], [27], [2]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1], [5], [27], [2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[2]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[2]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[2]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [5], [27], [2]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1], [5], [27], [2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[2]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[1], [5], [27], [2]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[51]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[1], [5], [52]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[2]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[2]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[2]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[1], [5], [27], [2]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1], [5], [27], [2]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[2]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1], [5], [27], [2]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[2]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[2]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[2]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[5], [59]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[2]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[2]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[2]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[62]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[2]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1], [5], [27], [2]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1], [5], [27], [2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [5], [27], [2]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[2]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[1], [5], [27], [2]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[1], [5], [27], [2]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[66]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[1], [68]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[2]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[2]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1], [5], [27], [2]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[2]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[71]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[72]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[2]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[2]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[1], [5], [27], [2]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1], [5], [27], [2]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1], [5], [27], [2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1], [5], [27]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1], [5], [27], [2]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[1], [5], [76]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[4]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3], [4]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [4]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3], [4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3], [4]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3], [4]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3], [4]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[2]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[26]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[2]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[33], [34]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[39]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[41]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[6], [1], [5]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[46]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[6], [5], [47], [48]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[5], [49], [34]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[5], [53]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[2]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[2]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [58]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [5], [60]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[61]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[2]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[1], [5], [67]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[69]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[62]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[5], [70]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[2]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[2]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[74]
D0956		Lovastatin	C24H36O5	53232	Minor		Inter Info	[2]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[75]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[77]
	CYP450 enzyme induction					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[5], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[5], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[5], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[5], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[5], [2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[5], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[5], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[5], [10], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[5], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[5], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[5], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[5], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[5], [10], [2]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[5], [2]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[5], [2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[5], [2]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[5], [2]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[5], [2]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[5], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[5], [2]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[5], [2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[5], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[5], [2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[5], [2]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[5], [2]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[5], [2]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[5], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[5], [2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[5], [2]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[5], [2]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[5], [2]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[5], [2]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[5], [2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[5], [2]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[5], [2]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[5], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[5], [56]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [57]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[5], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[5], [2]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[5], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[5], [2]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[5], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[5], [2]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[5], [2]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[5], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[5], [2]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[5], [2]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[6], [7], [8]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[9]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[12], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[13]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[6], [7], [8]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [5], [17], [18], [19], [20], [21], [22], [23], [24]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[25]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[35], [36], [37], [38]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[35], [36], [37], [38]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [40]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[42]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[14], [15], [16], [1], [5], [17], [18], [19], [20], [21], [22], [23], [24]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[44], [45]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [5], [17], [18], [19], [20], [21], [22], [23], [24]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[50]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[54]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [5], [17], [18], [19], [20], [21], [22], [23], [24]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[5], [55]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[35], [36], [37], [38]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [5], [63], [64], [65]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [73]
	Increased risk of hyperkalemia					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[2]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[2]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[2]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[2]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[2]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[2]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[2]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[2]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[2]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[2]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[2]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[2]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[2]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[2]
D1318		Potassium chloride	ClK	4873	Moderate		Inter Info	[2]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[2]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[2]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[2]
D1086		Monopotassium phosphate	H2KO4P	516951	Moderate		Inter Info	[2]
D1316		Potassium acetate	C2H3KO2	517044	Moderate		Inter Info	[2]
D1317		Potassium bicarbonate	CHKO3	516893	Moderate		Inter Info	[2]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[2]
D1320		Potassium gluconate	C6H11KO7	16760467	Moderate		Inter Info	[2]
D1321		Potassium Iodide	IK	4875	Moderate		Inter Info	[2]
D1322		Potassium perchlorate	ClKO4	516900	Moderate		Inter Info	[2]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[2]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[2]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[2]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[2]
	Increased risk of hypernatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[5], [2], [6]
D1482		Sodium chloride	ClNa	5234	Moderate		Inter Info	[5], [2], [6]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[5], [32], [2]

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