Drug General Information (ID: DDIX2EQO5L)
Drug Name			Trimipramine		Drug Info		Mestranol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Estrogens
Structure

Mechanism of Trimipramine-Mestranol Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Trimipramine				Mestranol
Mechanism 1		Tricyclic antidepressants				Inhibit the metabolism of tricyclic antidepressants
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Trimipramine caused by Mestranol
Mechanism 2		Tricyclic antidepressant				Inhibit the metabolism of tricyclic antidepressants
Key Mechanism Factor 2
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Trimipramine caused by Mestranol

References
1	Edelbroek PM, Zitman FG, Knoppert-van der Klein EA, van Putten PM, de Wolff FA "Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women." Clin Chim Acta 165 (1987): 177-87. [PMID: 3652444]
2	Khurana RC "Estrogen-imipramine interaction." JAMA 222 (1972): 702-3. [PMID: 4677904]
3	Somani SM, Khurana RC "Mechanism of estrogen-imipramine interaction." JAMA 223 (1973): 560. [PMID: 4739153]