Drug General Information (ID: DDIX20WR46)
Drug Name			Balsalazide		Drug Info		Norfloxacin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antibiotics
Structure

Mechanism of Balsalazide-Norfloxacin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Balsalazide				Norfloxacin
Mechanism		Balsalazide				Interference with the activation of balsalazide to mesalamine by intestinal bacteria
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Balsalazide when combined with Norfloxacin

Recommended Action
Management		If the patient must receive oral antibiotics, consideration should be given to using another 5-aminosalicylate such as mesalamine.

References
1	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.