Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIWSPONB2)
  Drug Name Nisoldipine Drug Info Calcium glycerophosphate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Minerals And Electrolytes
  Structure

 Mechanism of Nisoldipine-Calcium glycerophosphate Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nisoldipine Calcium glycerophosphate
      Mechanism Calcium channel blocker
Calcium channel unspecific  Blocker 		Decrease the effectiveness of calcium channel blockers by saturating calcium channels with calcium
Calcium-containing products 
      Key Mechanism Factor 1
Factor Name Voltage-dependent L-type calcium channel Structure Sequence
Protein Family Calcium channel beta subunit family
Protein Function
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Nisoldipine when combined with Calcium glycerophosphate 

Recommended Action
      Management Management consists of monitoring the effectiveness of calcium channel blocker therapy during coadministration with calcium products.

References
1 Woie L, Storstein L "Successful treatment of suicidal verapamil poisoning with calcium gluconate." Eur Heart J 2 (1981): 239-42
2 Oszko MA, Klutman NE "Use of calcium salts during cardiopulmonary resuscitation for reversing verapamil-associated hypotension." Clin Pharm 6 (1987): 448-9
3 Lipman J, Jardine I, Roos C, Dreosti L "Intravenous calcium chloride as an antidote to verapamil-induced hypotension." Intensive Care Med 8 (1982): 55-7