Drug General Information (ID: DDIWESTC2V)
Drug Name			Carteolol		Drug Info		Kaolin		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antihypertensive Agents				Herbal Products
Structure

Mechanism of Carteolol-Kaolin Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Carteolol				Kaolin
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Kaolin due to formation of complexes caused by Carteolol

References
1	D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17. [PMID: 2886325]
2	Hong CY, Hu SC, Lin SJ, Chiang BN "Lack of influence of aluminum hydroxide on the bioavailability and beta-adrenoceptor blocking activity of propranolol." Int J Clin Pharmacol Ther Toxicol 23 (1985): 244-6. [PMID: 4008113]
3	Regardh CG, Lundborg P, Persson BA "The effect of antacid, metoclopramide, and propantheline on the bioavailability of metoprolol and atenolol." Biopharm Drug Dispos 2 (1981): 79-87. [PMID: 7236872]