Drug General Information (ID: DDIVNP270W)
  Drug Name Propafenone Drug Info Amobarbital Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Anxiolytics/Sedatives/Hypnotics
  Structure

 Mechanism of Propafenone-Amobarbital Interaction (Severity Level: Minor)
     Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Propafenone Amobarbital
      Mechanism Propafenone Increase the hepatic metabolism of propafenone
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Increased metabolism of Propafenone caused by Amobarbital 

References
1 Sams RA, Muir WW. Effects of phenobarbital on thiopental pharmacokinetics in greyhounds. Am J Vet Res. 1988;49(2):245-249. [PMID: 3348533]