Drug General Information (ID: DDIVLJKRNM)
  Drug Name Acetylcysteine Drug Info Activated charcoal Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Expectorants/Antidotes Antidotes
  Structure

 Mechanism of Acetylcysteine-Activated charcoal Interaction (Severity Level: Minor)
     Adsorption Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetylcysteine Activated charcoal
      Mechanism Adsorbed by activated charcoal Activated charcoal
      Key Mechanism Factor 1
Factor Name Adsorption
Factor Description Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
      Mechanism Description
  • Decreased absorption of Acetylcysteine due to adsorption of Activated charcoal 

References
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2 Holdiness MR "Clinical pharmacokinetics of N-acetylcysteine." Clin Pharmacokinet 20 (1991): 123-34. [PMID: 2029805]
3 Mann KV "Treatment of acetaminophen overdose when oral acetylcysteine therapy is not tolerated." Clin Pharm 7 (1988): 563-4. [PMID: 3168413]
4 North DS, Peterson RG, Krenzelok EP "Effect of activated charcoal administration on acetylcysteine serum levels in humans." Am J Hosp Pharm 38 (1981): 1022-4. [PMID: 7258201]
5 Perrone J, Hoffman RS, Goldfrank LR "Special considerations in gastrointestinal decontamination." Emerg Med Clin North Am 12 (1994): 285-99. [PMID: 7910554]
6 Renzi FP, Donovan JW, Martin TG, Morgan L, Harrison EF "Concomitant use of activated charcoal and N-acetylcysteine." Ann Emerg Med 14 (1985): 568-72. [PMID: 3994080]
7 Rose SR "Subtleties of managing acetaminophen poisoning." Am J Hosp Pharm 51 (1994): 3065-8. [PMID: 7856628]
8 Smilkstein MJ "A new loading dose for N-acetylcysteine? The answer is no." Ann Emerg Med 24 (1994): 538-9. [PMID: 8080150]
9 Spiller HA, Krenzelok EP, Grande GA, Safir EF, Diamond JJ "A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose." Ann Emerg Med 23 (1994): 519-23. [PMID: 8135427]
10 Tenenbein PK, Sitar DS, Tenenbein M "Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning." Pharmacotherapy 21 (2001): 1331-6. [PMID: 11714205]
11 Watson WA, McKinney PE "Activated charcoal and acetylcysteine absorption: issues in interpreting pharmacokinetic data." DICP 25 (1991): 1081-4. [PMID: 1803797]