Details of Drug | MecDDI

Drug General Information (ID: D0016)
Drug Name		Acetylcysteine
Drug Type		Small molecule
Drug Synonymous		Acetadone EF; Acetadote ALF; Acetylcysteine, Cumberland Pharmaceuticals Click to Show/Hide
Disease Class		DB90-DB9Z: Liver disease
Therapeutic Class		Expectorants/Antidotes
Structure
Structure		3D Structure				2D Structure
Formula		C5H9NO3S
InChI		1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChIKey		PWKSKIMOESPYIA-BYPYZUCNSA-N
Canonical SMILES		CC(=O)NC(CS)C(=O)O
External Link
		Pubchem ID		12035
		CAS Number		616-91-1
		CHEBI ID		28939
		TTD ID		D06XGW
		VARIDT ID		DR00874

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption BM004 Adsorption BM009 Altered absorption (Unspecific)
Relation Graph

Full list of drugs interacting with Acetylcysteine
Affected gastrointestinal absorption
					Adsorption																																																																Drug Num: 1
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0021															Activated charcoal															C															5462310															Minor															Inter Info													[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
					Altered absorption (Unspecific)																																																																Drug Num: 1
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0814															Insulin human (inhalation, rapid acting)															C257H383N65O77S6															118984375															Moderate															Inter Info													[1], [2], [3]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
3	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
4	Brent J "Are activated charcoal-N-acetylcysteine interactions of clinical significance?" Ann Emerg Med 22 (1993): 1860-2. [PMID: 8239109]
5	Holdiness MR "Clinical pharmacokinetics of N-acetylcysteine." Clin Pharmacokinet 20 (1991): 123-34. [PMID: 2029805]
6	Mann KV "Treatment of acetaminophen overdose when oral acetylcysteine therapy is not tolerated." Clin Pharm 7 (1988): 563-4. [PMID: 3168413]
7	North DS, Peterson RG, Krenzelok EP "Effect of activated charcoal administration on acetylcysteine serum levels in humans." Am J Hosp Pharm 38 (1981): 1022-4. [PMID: 7258201]
8	Perrone J, Hoffman RS, Goldfrank LR "Special considerations in gastrointestinal decontamination." Emerg Med Clin North Am 12 (1994): 285-99. [PMID: 7910554]
9	Renzi FP, Donovan JW, Martin TG, Morgan L, Harrison EF "Concomitant use of activated charcoal and N-acetylcysteine." Ann Emerg Med 14 (1985): 568-72. [PMID: 3994080]
10	Rose SR "Subtleties of managing acetaminophen poisoning." Am J Hosp Pharm 51 (1994): 3065-8. [PMID: 7856628]
11	Smilkstein MJ "A new loading dose for N-acetylcysteine? The answer is no." Ann Emerg Med 24 (1994): 538-9. [PMID: 8080150]
12	Spiller HA, Krenzelok EP, Grande GA, Safir EF, Diamond JJ "A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose." Ann Emerg Med 23 (1994): 519-23. [PMID: 8135427]
13	Tenenbein PK, Sitar DS, Tenenbein M "Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning." Pharmacotherapy 21 (2001): 1331-6. [PMID: 11714205]
14	Watson WA, McKinney PE "Activated charcoal and acetylcysteine absorption: issues in interpreting pharmacokinetic data." DICP 25 (1991): 1081-4. [PMID: 1803797]