Drug General Information (ID: DDIVCR0J6O)
Drug Name			Vitamin E		Drug Info		Ferrous gluconate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Iron Supplement
Structure

Mechanism of Vitamin E-Ferrous gluconate Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Vitamin E				Ferrous gluconate
Mechanism		Diminish the therapeutic response to iron therapy in patients with iron deficiency anemia				Iron oral
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Vitamin E when combined with Ferrous gluconate

Recommended Action
Management		Patients receiving iron therapy for iron deficiency anemia should be monitored for potentially reduced hematologic response if vitamin E is administered concomitantly.

References
1	Graeber JE, Williams ML, Oski FA "The use of intramuscular vitamin E in the premature infant. Optimum dose and iron interaction." J Pediatr 90 (1977): 282-4
2	Melhorn DK, Gross S "Relationships between iron-dextran and vitamin E in iron deficiency anemia in children." J Lab Clin Med 74 (1969): 789-802