Details of Drug

Details of Drug

 Drug General Information (ID: D1703)
  Drug Name
Vitamin E
  Drug Type Small molecule
  Drug Synonymous
Covi-ox; VITAMIN E; E-Vimin; Syntopherol; Profecundin; Evitaminum; Viprimol; Vascuals; Etamican; Viteolin; Tokopharm; Vitayonon; Epsilan; Emipherol; Denamone; Almefrol; Verrol; Ilitia; Etavit; 77171-98-3; Evion; Esorb; alpha-Tokoferol; alpha Tocopherol; Vitaplex E; Vitamin E alpha; Eprolin S; Viterra E; E Prolin; Spavit E; Vita E; Endo E; Med-E; Lan-E; Antisterility vitamin; alpha-Tocopherol acid; Tenox GT 1; (R)-2,5,7,8-tetramethyl-2-((4S,8S)-4,8,12-trimethyltridecyl)chroman-6-ol; Rhenogran Ronotec 50; Vi-E; Covitol F 1000; E 307 (tocopherol)
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  Disease Class BA00-BE2Z: Cardiovascular disease
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C29H50O2
  InChI 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
  InChIKey GVJHHUAWPYXKBD-IEOSBIPESA-N
  Canonical SMILES CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
  External Link
Pubchem ID 14985
CAS Number 21590
CHEBI ID 18145
TTD ID D02TQO
INTEDE ID DR1608

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM008  Altered Fat-soluble drugs absorption
BM050  Increased risk of bleeding
BM107  Attenuated pharmacological effects (Unspecific)
BM110  Antagonize the effects of immunosuppressants
  Relation Graph
 Full list of drugs interacting with Vitamin E
      Affected gastrointestinal absorption
   Altered Fat-soluble drugs absorption Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0329
 
Cholestyramine
 
C27H47ClN2
 
137699107 
Moderate    Inter Info   
[25], [3], [26], [27], [28], [29]
D0381
 
Colesevelam
 
C31H67Cl3N4O
 
160051 
Moderate    Inter Info   
[25], [3], [26], [27], [28], [29]
D0382
 
Colestipol
 
C11H28ClN5O
 
62816 
Moderate    Inter Info   
[25], [3], [26], [27], [28], [29]
D1462
 
Sevelamer
 
C6H12ClNO
 
3085017 
Moderate    Inter Info   
[25], [3], [26], [27], [28], [29]
D1187
 
Orlistat
 
C29H53NO5
 
3034010 
Minor    Inter Info   
[35]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  41
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Major    Inter Info   
[1], [2], [3], [4]
D1592
 
Tipranavir
 
C31H33F3N2O5S
 
54682461 
Major    Inter Info   
[5]
D0005
 
Abciximab
 
NA
 
NA
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0537
 
Drotrecogin alfa
 
NA
 
NA
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0588
 
Eptifibatide
 
C35H49N11O9S2
 
448812 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Moderate    Inter Info   
[11], [13], [15]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Moderate    Inter Info   
[11], [13], [15]
D0093
 
Antithrombin III human
 
NA
 
NA
Moderate    Inter Info   
[11], [13], [15]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0250
 
Caplacizumab
 
NA
 
NA
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0415
 
Danaparoid
 
NA
 
NA
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0435
 
Defibrotide
 
C20H21N4O6P
 
135565962 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0447
 
Desirudin
 
C287H440N80O110S6
 
16129703 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[11], [13], [15]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1360
 
Protein C
 
NA
 
NA
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1581
 
Ticlopidine
 
C14H14ClNS
 
5472 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1593
 
Tirofiban
 
C22H36N2O5S
 
60947 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[6], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0647
 
Ferric carboxymaltose
 
C24H44FeO25-
 
86278165 
Moderate    Inter Info   
[30], [31]
D0648
 
Ferric derisomaltose
 
C18H34FeO16+3
 
86278348 
Moderate    Inter Info   
[30], [31]
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Moderate    Inter Info   
[30], [31]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Moderate    Inter Info   
[30], [31]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Moderate    Inter Info   
[30], [31]
D0654
 
Ferumoxytol
 
Fe3H2O4
 
14789 
Moderate    Inter Info   
[30], [31]
D0847
 
Iron
 
Fe
 
23925 
Moderate    Inter Info   
[30], [31]
D0848
 
Iron Dextran
 
FeH2O4S
 
105075 
Moderate    Inter Info   
[30], [31]
D0849
 
Iron protein succinylate
 
NA
 
NA
Moderate    Inter Info   
[30], [31]
D0850
 
Iron sucrose
 
C12H29Fe5Na2O23
 
91663255 
Moderate    Inter Info   
[30], [31]
D1484
 
Sodium ferric gluconate complex
 
C6H11FeNaO7+3
 
23693558 
Moderate    Inter Info   
[30], [31]
   Antagonize the effects of immunosuppressants Drug Num:  59
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0023
 
Adalimumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0032
 
Alefacept
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0085
 
Anakinra
 
C20H23N5O7S2
 
146171046 
Minor    Inter Info   
[32], [33], [34]
D0094
 
Antithymocyte immunoglobulin (rabbit)
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0147
 
Basiliximab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Minor    Inter Info   
[32], [33], [34]
D0553
 
Efalizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0614
 
Etanercept
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0802
 
Infliximab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1093
 
Muromonab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1111
 
Natalizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1176
 
Omalizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1416
 
Rituximab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0004
 
Abatacept
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0091
 
Antilymphocyte immunoglobulin (horse)
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Minor    Inter Info   
[32], [33], [34]
D0146
 
Baricitinib
 
C16H17N7O2S
 
44205240 
Minor    Inter Info   
[32], [33], [34]
D0151
 
Belatacept
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0152
 
Belimumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Minor    Inter Info   
[32], [33], [34]
D0209
 
Brodalumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Minor    Inter Info   
[32], [33], [34]
D0246
 
Canakinumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0304
 
Certolizumab pegol
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Minor    Inter Info   
[32], [33], [34]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Minor    Inter Info   
[32], [33], [34]
D0540
 
Dupilumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0541
 
Durvalumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Minor    Inter Info   
[32], [33], [34]
D0736
 
Golimumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0747
 
Guselkumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Minor    Inter Info   
[32], [33], [34]
D0801
 
Inebilizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0875
 
Ixekizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Minor    Inter Info   
[32], [33], [34]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Minor    Inter Info   
[32], [33], [34]
D1083
 
Mogamulizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Minor    Inter Info   
[32], [33], [34]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Minor    Inter Info   
[32], [33], [34]
D1162
 
Ocrelizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Minor    Inter Info   
[32], [33], [34]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Minor    Inter Info   
[32], [33], [34]
D1403
 
Rilonacept
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1410
 
Risankizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1447
 
Sarilumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1448
 
Satralizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1454
 
Secukinumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1467
 
Siltuximab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Minor    Inter Info   
[32], [33], [34]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Minor    Inter Info   
[32], [33], [34]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Minor    Inter Info   
[32], [33], [34]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Minor    Inter Info   
[32], [33], [34]
D1583
 
Tildrakizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1599
 
Tocilizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Minor    Inter Info   
[32], [33], [34]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Minor    Inter Info   
[32], [33], [34]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Minor    Inter Info   
[32], [33], [34]
D1671
 
Ustekinumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
D1685
 
Vedolizumab
 
NA
 
NA
Minor    Inter Info   
[32], [33], [34]
References
1 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2 Cerner Multum, Inc. "Canadian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
5 Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
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27 Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
28 Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
29 Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
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35 Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.