Drug General Information (ID: DDIV2DE6KL)
Drug Name			Sucralfate		Drug Info		Alendronic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Bone Density Conservation Agents
Structure

Mechanism of Sucralfate-Alendronic acid Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Alendronic acid
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Alendronic acid

Recommended Action
Management		Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.

References
1	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
2	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
3	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.