Drug General Information (ID: DDIUZGKMLW)
Drug Name			Baloxavir marboxil		Drug Info		Zinc acetate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Minerals And Electrolytes
Structure

Mechanism of Baloxavir marboxil-Zinc acetate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Baloxavir marboxil				Zinc acetate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Zinc acetate due to formation of complexes caused by Baloxavir marboxil

Recommended Action
Management		Concurrent administration of baloxavir marboxil with polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., aluminum, calcium, iron, magnesium, selenium, zinc) should generally be avoided.

References
1	Product Information. Xofluza (baloxavir marboxil). Genentech, South San Francisco, CA.