Details of Drug-Drug Interaction
| Drug General Information (ID: DDIURKYJWT) | |||||||||
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| Drug Name | Nalidixic acid | Drug Info | Kaolin | Drug Info | |||||
| Drug Type | Small molecule | Natural product | |||||||
| Therapeutic Class | Antibiotics | Herbal Products | |||||||
| Structure | |||||||||
| Mechanism of Nalidixic acid-Kaolin Interaction (Severity Level: Moderate) | |||||||||
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| Complex formation Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Nalidixic acid | Kaolin | |||||||
| Mechanism | Binds to polyvalent cations | Polyvalent cations | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Chelation | ||||||||
| Factor Description | Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | When coadministration cannot be avoided, nalidixic acid should be dosed at least 2 hours before or 2 hours after polyvalent cation-containing products to minimize the potential for interaction. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. NegGram (nalidixic acid). Sanofi Winthrop Pharmaceuticals, New York, NY. | ||||||||||||||||||