Drug General Information (ID: DDIUMVL35Q)
Drug Name			Cyclosporine		Drug Info		Sucralfate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Gi Agents
Structure

Mechanism of Cyclosporine-Sucralfate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Sucralfate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Cyclosporine

Recommended Action
Management		Oral cyclosporine should be administered 2 hours before or 6 hours after the aluminum salt in order to avoid this potential interaction. The patient's therapeutic response should be monitored.

References
1	Ichisawa M, Ohta I, Suzuki R, et al. "The effect of dried aluminum hydroxide gel on the blood concentration of cyclosporine-A." Jpn J Hosp Pharm 23 (1997): 407-13.