Drug General Information (ID: DDIUKNDASL)
Drug Name			Calcipotriol (topical)		Drug Info		Estrone sulfate (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsoriatic Agents				Estrogens
Structure

Mechanism of Calcipotriol (topical)-Estrone sulfate (topical) Interaction (Severity Level: Moderate)
Increased risk of hypercalcemia Click to Show/Hide Mechanism Graph
Drug Name		Calcipotriol (topical)				Estrone sulfate (topical)
Mechanism		Hypercalcemia				Hypercalcemia
Key Mechanism Factor 1
		Factor Name		Hypercalcemia
		Factor Description		Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.
Mechanism Description		Increased risk of hypercalcemia by the combination of Calcipotriol (topical) and Estrone sulfate (topical)

Recommended Action
Management		Calcium and vitamin D status should be monitored closely when topical vitamin D analogs are used in combination with systemic vitamin D products or other agents that can increase serum calcium levels.

References
1	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
2	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.