Drug General Information (ID: DDIUIOMEZ0)
Drug Name			Azithromycin		Drug Info		Disopyramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Macrolides				Antiarrhythmic Agents
Structure

Mechanism of Azithromycin-Disopyramide Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Azithromycin				Disopyramide
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Azithromycin and Disopyramide

Recommended Action
Management		The concurrent use of disopyramide with other medications that can prolong the QT interval should generally be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if these agents are prescribed together, especially to patients with underlying risk factors. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope.

References
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11	Product Information. Erythrocin Lactobionate (erythromycin). Abbott Pharmaceutical, Abbott Park, IL.
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