Details of Drug

Drug General Information (ID: D0139)
Drug Name	Azithromycin
Drug Type	Small molecule
Drug Synonymous	azithromycin; Zithromax; 83905-01-5; Azithromycinum; Azithromycine; Sumamed; Zitromax; Zmax; Hemomycin; Azitrocin; Azasite; Azenil; Aritromicina; Zitrotek; Zithrax; Mixoterin; Setron; Aziwok; Zitrim; Aztrin; Zifin; Tobil; Zmas; Zeto; Azithromycinum [Latin]; Azithromycine [French]; Zithromax IV; AZITHROMYCIN DIHYDRATE; Misultina; Azitromax; Z-Pak; Tromix; Aritromicina [Spanish]; Azitromicina; CP-62993; UNII-J2KLZ20U1M; DRG-0104; CCRIS 1961; HSDB 7205; Azithromycin (anhydrous); C38H72N2O12; BRN 5387583; J2KLZ20U1M; Azythromycin; CHEBI:2955 Click to Show/Hide
Disease Class	1A61-1A6Z: Syphilis
Therapeutic Class	Macrolides
Structure
Structure	3D Structure		2D Structure
Formula	C38H72N2O12
InChI	1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChIKey	MQTOSJVFKKJCRP-BICOPXKESA-N
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
External Link
	Pubchem ID	447043
	CAS Number	83905-01-5
	CHEBI ID	2955
	TTD ID	D03HJK
	INTEDE ID	DR0168
	VARIDT ID	DR00367

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM003 Complex formation BM010 Transporter inhibition BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM049 Increased risk of atrioventricular block BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Azithromycin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[401], [402]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[401], [402]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[413], [302], [303]
	Complex formation					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[63]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[63]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[63]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[63]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[11], [431]
Affected cellular transport
	Transporter inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[24]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[25], [26], [27]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[52], [53], [54]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[11], [69], [70], [71]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[10], [11], [152], [153]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[9], [11], [215], [216]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[10], [11], [300]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[326], [155], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[326], [155], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[366], [10], [11], [367], [368], [369], [370], [371], [372]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[23]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[11], [403]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[366], [10], [11], [367], [368], [369], [370], [371], [372]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[366], [370], [371]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[10], [11], [434]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[10], [435]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[442]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[454]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[459]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[385]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[155], [156], [157], [158], [159], [160], [161], [162]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[163]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[217], [155], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[308], [309], [11], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[308], [309], [11], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[310], [312], [313]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[308], [309], [11], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[310], [312], [313]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[310], [312], [313]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[217], [155], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[436]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[217], [155], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[325]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[455]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[11], [107], [398]
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[155], [248], [249], [250], [251], [252], [253], [254], [255], [63], [256], [257], [258], [259], [260]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[248], [63], [259]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[155], [248], [249], [250], [251], [252], [253], [254], [255], [63], [256], [257], [258], [259], [260]
	Increased risk of hepatotoxicity					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[9], [121], [122]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[138]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[154]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[197], [198], [199], [10], [11], [200], [201], [202], [203], [204], [205], [206], [207]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[305], [306], [307]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[197], [198], [199], [10], [11], [200], [201], [202], [203], [204], [205], [206], [207]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[11], [322]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[384]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [399]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[404]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[407], [408], [409], [410]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[446], [447]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [448]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[407], [408], [409], [410]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[407], [408], [409], [410]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[197], [198], [199], [10], [11], [200], [201], [202], [203], [204], [205], [206], [207]
	Increased risk of prolong QT interval					Drug Num: 161
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[8]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[9], [10], [11], [12]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[15]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[9], [10], [11], [16], [17], [3], [18], [19], [20], [21], [22], [7], [23]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[11], [28]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[9], [10], [11], [29]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[30], [11], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[9], [10], [11], [49], [50], [23], [51]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[10], [11], [55], [56], [57], [58], [59], [60], [61], [62], [4], [63], [64]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[9], [10], [11], [65]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[9], [10], [11], [66]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[9], [10], [11], [67], [68], [23]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[72]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[9], [73], [10], [11], [74], [75], [23]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[77], [78], [79], [9], [10], [11], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[78], [9], [10], [11], [100], [101], [102]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[103], [9], [10], [11], [104], [105], [106], [107], [108]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[9], [10], [11], [109], [110], [111], [112], [113], [114], [23]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[57], [60], [62], [115], [4], [63]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[9], [10], [11], [116], [23]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[119]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[120]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[11], [123], [23]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[10], [11], [124]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[125]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[9], [10], [11], [126], [23]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[9], [10], [11], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [23]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[9], [10], [11], [137]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[77], [78], [79], [9], [10], [11], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[9], [10], [11], [139]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[140]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[142]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[143], [144], [145], [146], [147], [148], [149], [150]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[9], [10], [11], [151]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[9], [10], [11], [16], [17], [3], [18], [19], [20], [21], [22], [7], [23]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[9], [10], [11], [16], [17], [3], [18], [19], [20], [21], [22], [7], [23]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[9], [10], [11], [67], [84], [164], [165], [23]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[166], [167], [9], [10], [11], [168], [169]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[11], [170]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[9], [10], [11], [16], [17], [3], [18], [19], [20], [21], [22], [7], [23]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[78], [9], [10], [11], [172], [173], [82], [84], [86], [174], [87], [88], [175], [90], [91], [92], [93], [176], [97], [102], [177]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[9], [10], [11], [178], [67], [179], [180], [181], [23]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[9], [10], [11], [182]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[9], [10], [11], [185]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[9], [10], [11], [186]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[9], [10], [11], [67], [188], [23]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[9], [10], [11], [189]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[84], [165], [23]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[9], [10], [11], [261], [23]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[10], [11], [292], [293], [294], [295], [296], [297]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[9], [10], [11], [298], [23]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[11], [304]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[323]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[324]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[84], [165], [23]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[84], [165], [23]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[84], [165], [23]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[9], [10], [11], [376]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[380]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[78], [86], [87], [92], [381]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[382]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[383]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[11], [386]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[78], [9], [10], [11], [82], [83], [84], [387], [388], [87], [88], [389], [89], [390], [90], [91], [92], [93], [391], [392], [393], [97], [102]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[11]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[9], [10], [11], [394], [23]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[395], [396]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[9], [10], [397]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[400]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[78], [9], [10], [11], [82], [83], [84], [387], [388], [87], [88], [389], [89], [390], [90], [91], [92], [93], [391], [392], [393], [97], [102]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[78], [9], [10], [11], [82], [83], [84], [387], [388], [87], [88], [389], [89], [390], [90], [91], [92], [93], [391], [392], [393], [97], [102]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[10], [11], [405]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[11], [406]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[411], [412]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[414]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[417], [418], [419], [420], [421], [422], [423], [424], [425], [426]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[9], [10], [11], [67], [427], [428], [429], [430], [23]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[432], [433]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[9], [10], [11], [437]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[9], [10], [11], [438]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[439], [440], [63], [441]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[9], [10], [11], [443], [160], [162]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[9], [10], [11], [444], [23]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[449], [450], [292], [451], [452], [453], [23]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[11], [190], [191], [192], [193], [194], [195], [196]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[9], [10], [11], [67], [84], [165], [23]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[10], [456], [457], [458]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[9], [10], [11], [460], [461], [462], [463]
	Increased risk of ventricular arrhythmias					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[13], [14]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[9], [10], [11], [76], [51]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[11], [117], [118]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[141]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [171]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[9], [208], [10], [11], [209], [210], [211], [212], [213], [214]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[9], [10], [11], [373], [374], [375]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[10], [11], [303]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[9], [10], [11], [373], [374], [375]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[275], [285], [288]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[275], [285], [288]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[9], [10], [11], [301], [302], [303]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[11], [415], [416]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[10], [11], [303]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[9], [10], [11], [373], [374], [375]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[11], [415], [416]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[9], [10], [11], [373], [374], [375]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[10], [11], [445]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[275], [285], [288]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[11], [183], [184]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[187]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[299]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[377], [378], [379]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[377], [378], [379]

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161	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
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171	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
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186	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
187	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
188	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
189	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
190	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
191	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
192	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
193	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
194	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
195	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
196	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
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204	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
205	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
206	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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278	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
279	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
280	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
281	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
282	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
283	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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319	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
320	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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