Details of Drug Interaction

Drug General Information (ID: DDIUDNVQ7F)
Drug Name		Entacapone	Drug Info		Memantine	Drug Info
Drug Type	Small molecule			Small molecule
Therapeutic Class	Antiparkinson Agents			Cholinesterase Inhibitors
Structure

Mechanism of Entacapone-Memantine Interaction (Severity Level: Minor)
Additive dopaminergic effects Click to Show/Hide Mechanism Graph

Drug Name	Entacapone		Memantine
Mechanism	Dopaminergic effects Catechol-O-methyl-transferase Inhibitor		Dopaminergic effects Dopamine receptor Agonist
Key Mechanism Factor 1
	Factor Name	Catechol-O-methyl-transferase		× Structure Sequence MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
	Gene Name	COMT
	Uniprot ID	COMT_HUMAN
	KEGG Pathway	hsa:1312
	Protein Family	Class I-like SAM-binding methyltransferase superfamily
	Protein Function	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Click to Show/Hide
Key Mechanism Factor 2
	Factor Name	Dopamine receptor		Structure Sequence
	Protein Family	G-protein coupled receptor 1 family
	Protein Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Click to Show/Hide
Mechanism Description	Additive dopaminergic effects by the combination of Entacapone and Memantine

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.

Details of Drug-Drug Interaction