Details of Drug-Drug Interaction
| Drug General Information (ID: DDIUD8OQNS) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Didanosine | Drug Info | Darunavir | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anti-Hiv Agents | Antiviral Agents | |||||||
| Structure | |||||||||
| Mechanism of Didanosine-Darunavir Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Didanosine | Darunavir | |||||||
| Mechanism | Didanosine | Decrease absorption of didanosine | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetic | ||||||||
| Factor Description | Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
|
||||||||
| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Combination products containing darunavir, including darunavir-ritonavir and darunavir-cobicistat should be taken with food at least two hours before or one hour after didanosine. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ. | ||||||||||||||||||