Drug General Information (ID: DDIU1BZONT)
  Drug Name Ranitidine (bismuth citrate) Drug Info Didanosine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiulcer Agents Anti-Hiv Agents
  Structure

 Mechanism of Ranitidine (bismuth citrate)-Didanosine Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ranitidine (bismuth citrate) Didanosine
      Mechanism Gastric alkalinizer Gastric pH sensitive
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Didanosine due to altered gastric pH caused by Ranitidine (bismuth citrate) 

References
1 Knupp CA, Graziano FM, Dixon RM, Barbhaiya RH "Pharmacokinetic-interaction study of didanosine and ranitidine in patients seropositive for human immunodeficiency virus." Antimicrob Agents Chemother 36 (1992): 2075-9. [PMID: 1444287]
2 Product Information. Videx (didanosine). Bristol-Myers Squibb, Princeton, NJ.