Drug General Information (ID: DDITZ849WN)
Drug Name			Sucralfate		Drug Info		Ketoconazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antifungal Agents
Structure

Mechanism of Sucralfate-Ketoconazole Interaction (Severity Level: Minor)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Ketoconazole
Mechanism		Decrease absorption of ketoconazole				Ketoconazole
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Ketoconazole caused by Sucralfate

References
1	Carver PL, Berardi RR, Knapp MJ, Rider JM, Kauffman CA, Bradley SF, Atassi M "In vivo interaction of ketoconazole and sucralfate in healthy volunteers." Antimicrob Agents Chemother 38 (1994): 326-9. [PMID: 7910724]
2	Hoeschele JD, Roy AK, Pecoraro VL, Carver PL "In vitro analysis of the interaction between sucralfate and ketoconazole." Antimicrob Agents Chemother 38 (1994): 319-25. [PMID: 7910723]
3	Piscitelli SC, Goss TF, Wilton JH, D'Andrea DT, Goldstein H, Schentag JJ "Effects of ranitidine and sucralfate on ketoconazole bioavailability." Antimicrob Agents Chemother 35 (1991): 1765-71. [PMID: 1952845]