Drug General Information (ID: DDITYM9E7L)
Drug Name			Flibanserin		Drug Info		Chlorcyclizine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Agents				Antihistamines
Structure

Mechanism of Flibanserin-Chlorcyclizine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Flibanserin				Chlorcyclizine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Flibanserin and Chlorcyclizine

Recommended Action
Management		Patients receiving flibanserin with other agents that can cause CNS depression should be apprised of the potential for increased adverse effects such as drowsiness, dizziness, lightheadedness, and fatigue. Patients should not drive, operate machinery, or engage in hazardous activities requiring mental alertness and motor coordination for at least 6 hours after taking flibanserin.

References
1	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.