Details of Drug

Drug General Information (ID: D0316)
Drug Name	Chlorcyclizine
Drug Type	Small molecule
Drug Synonymous	chlorcyclizine; Chlorcycline; Alergicide; Perazyl; 82-93-9; Chlorocycline; Trihistan; Chlorocyclizine; Histantine; Di-paralen; Histachlorazene; Diparalene; Histantin; Compound 47-282; Chlorcyclizine free base; 1-(4-Chlorobenzhydryl)-4-methylpiperazine; N-Methyl-N'-(4-chlorobenzhydryl)piperazine; NSC 25246; Di-Paralene; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; CHEMBL22150; Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-; Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-; NSC25246; 1-((4-Chlorophenyl)phenylmethyl)-4-methylpiperazine; 1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine; NSC-25246; 82-93-9 (FREE BASE); 1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazine; Piparalene; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-methylpiperazine; Clorciclizina [DCIT]; Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-methyl-; Chlorcyclizinum; Clorciclizina; Clorciclizinio; Chlorcyclizine [INN:BAN]; Chlorcyclizinum [INN-Latin]; Clorciclizinio [INN-Spanish]; HSDB 3217; EINECS 201-446-0; BRN 0272719; 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine; Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-; Prestwick0_000706; Prestwick1_000706; Prestwick2_000706; Prestwick3_000706; SCHEMBL4383; Oprea1_854942; BSPBio_000891; DivK1c_000210; SPBio_002812; BPBio1_000981; DTXSID9048011; CHEBI:94402; KBio1_000210; COMPD 47-282; NINDS_000210; Chlorcyclizine, >=98% (HPLC); BDBM50329371; PDSP1_000150; PDSP2_000149; AKOS015962157; DB08936; MCULE-4720374498; WLN: T6N DNTJ AYR&R DG& D1; IDI1_000210; NCGC00179384-01; NCGC00179384-10; AC-15952; SBI-0206679.P002; AB00053788; AB00053788_09; Q2393323; BRD-A57133233-003-03-7; BRD-A57133233-003-06-0; 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine; 1-[(4-Chloro-phenyl)-phenyl-methyl]-4-methyl-piperazine; Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl- (9CI) Click to Show/Hide
Therapeutic Class	Antihistamines
Structure
Structure	3D Structure		2D Structure
Formula	C18H21ClN2
InChI	InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
InChIKey	WFNAKBGANONZEQ-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
External Link
	Pubchem ID	2710
	VARIDT ID	DR01215

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM033 Additive anticholinergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM054 Increased risk of GI mucosal injury/bleeding risk BM061 Increased risk of hyperpyrexia BM091 Antagonize the effect of cholinergic agents BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Chlorcyclizine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[66], [67], [68]
Affected intra/extra-hepatic metabolism
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 83
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[34], [35]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[41], [43], [49]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[41], [43], [49]
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[55], [56], [57]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[55], [56], [57]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[41], [43], [49]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[41], [43], [49]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[41], [43], [49]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[41], [43], [49]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[21], [23], [24]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[41], [43], [49]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[41], [43], [49]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[41], [43], [49]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[41], [43], [49]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[41], [43], [49]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[78], [97], [79]
	Additive antimotility effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[91]
	Additive CNS depression effects					Drug Num: 69
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[13], [14]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[15], [16], [17]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[18]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[19]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[28], [29], [30]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[31], [32], [33]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[51], [52]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[53], [30], [54]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[53], [30], [54]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[53], [30], [54]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[31], [32], [33]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[31], [32], [33]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[31], [32], [33]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[31], [32], [33]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[60], [61]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[31], [32], [33]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[62]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[31], [32], [33]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[31], [32], [33]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[64], [65]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[31], [32], [33]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[69]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[31], [32], [33]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[31], [32], [33]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[31], [32], [33]
D1183		Opium	NA	NA	Moderate		Inter Info	[31], [32], [33]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[31], [32], [33]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[31], [32], [33]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[31], [32], [33]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[31], [32], [33]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[31], [32], [33]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[31], [32], [33]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[31], [32], [33]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[31], [32], [33]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[31], [32], [33]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[67], [78], [66], [30], [79]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[31], [32], [33]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[80]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[31], [32], [33]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[31], [32], [33]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[82], [67], [83]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[84], [64], [30], [85], [86], [87], [88], [89], [90]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[60], [61]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[31], [32], [33]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[84], [64], [30], [85], [86], [87], [88], [89], [90]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[31], [32], [33]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[31], [32], [33]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[31], [32], [33]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[31], [32], [33]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[31], [32], [33]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[31], [32], [33]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[67], [92], [79]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[31], [32], [33]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[31], [32], [33]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[84], [64], [30], [85], [86], [87], [88], [89], [90]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[31], [32], [33]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[31], [32], [33]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[84], [64], [30], [85], [86], [87], [88], [89], [90]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[31], [32], [33]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[31], [32], [33]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[31], [32], [33]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[31], [32], [33]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[31], [32], [33]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[31], [32], [33]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[31], [32], [33]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[93]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[31], [32], [33]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[84], [86], [88]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[31], [32], [33]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[1], [3], [6]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[30], [63]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[58], [59]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[58], [59]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[58], [59]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
	Diminish the response to diagnostic skin test antigens					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[58], [67], [71]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[58], [67], [71]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[30], [70], [67]
D1807		Histamine	C5H9N3	774	Moderate		Inter Info	[79], [67], [81]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[94], [95], [96]

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