Drug General Information (ID: DDITQHPGSB)
Drug Name			Sucralfate		Drug Info		Deferiprone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Chelating Agents
Structure

Mechanism of Sucralfate-Deferiprone Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Deferiprone
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Deferiprone

Recommended Action
Management		A minimum 4-hour interval is recommended between the administration of deferiprone and mineral supplements or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) or other polyvalent cations.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.