Drug General Information (ID: DDITLCN3V7)
Drug Name			Spironolactone		Drug Info		Mitotane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antineoplastics
Structure

Mechanism of Spironolactone-Mitotane Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Spironolactone				Mitotane
Mechanism		Inhibit the adrenolytic effects of mitotane				Mitotane
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Mitotane when combined with Spironolactone

Recommended Action
Management		This combination should be avoided. If these drugs must be used together, the biochemical effects of mitotane should be closely monitored.

References
1	Wortsman J, Soler NG "Mitotane: spironolactone antagonism in Cushing's syndrome." JAMA 238 (1977): 2527.[PMID: 578890]