Details of Drug

Drug General Information (ID: D1078)
Drug Name	Mitotane
Drug Type	Small molecule
Drug Synonymous	Chloditan; Chlodithan; Chlodithane; Khloditan; Khlodithan; Lysodren; Mitotan; Mitotano; Mitotanum; Mytotan; Bristol Myers Squibb Brand of Mitotane; C 3010; CB 313; CB313; PS694_SUPELCO; Bristol-Myers Squibb Brand of Mitotane; CB-313; Lysodren (TN); Mitotano [INN-Spanish]; Mitotanum [INN-Latin]; Ortho,para DDD; Mitotane [USAN:INN:JAN]; O,p-DDD; O,p-Tde; Ortho,para-DDD; Mitotane (JAN/USP/INN); O,p'-DDD; O,p'-Dichlorodiphenyldichloroethane; O,p'-TDE; Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-(8CI); (+-)-1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; (2,4'-Dichlorodiphenyl)dichloroethane; (o,p)-DDD; 1,1-Dichloro-2,2-bis(2,4'-dichlorophenyl)ethane; 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,1-Dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane; 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; 2,4'-Ddd; 2,4'-Dichlorodiphenyldichloroethane; 2,4'-Dichlorophenyldichlorethane; 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloroethane Click to Show/Hide
Disease Class	2D11: Adrenal cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C14H10Cl4
InChI	1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChIKey	JWBOIMRXGHLCPP-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
External Link
	Pubchem ID	4211
	CAS Number	53-19-0
	CHEBI ID	6954
	TTD ID	D0Z5OE

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Mitotane
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[341]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[132]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[148]
	CYP450 enzyme induction					Drug Num: 262
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[1], [2], [3]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[10], [11], [12]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[20], [21], [22], [14], [4], [23], [24], [25], [26], [2], [27], [28], [29]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[30], [13], [14], [4], [31], [32]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[1], [2], [3]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[45]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[46]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[47]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[48]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[49], [50], [51]
D0099		Apremilast	C22H24N2O7S	11561674	Major		Inter Info	[52]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[14], [4], [53]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[4], [54]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[55], [56]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[4], [57]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [18], [2]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3]
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[4], [58], [59]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[60]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[61]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[62]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[63], [64]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[65]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[66]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[14], [4], [67], [68], [69]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[14], [4], [70]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[71]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[14], [72], [4], [73]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[4], [74]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[14], [4], [75]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[4]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[76], [77], [78], [79], [80], [81]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[82]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[83]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[14], [84]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[14], [4], [85], [67], [68], [69]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[86]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[87]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[88]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[89]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[90]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[13], [14], [4], [91], [92]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[4], [93]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[1], [2], [3]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[14], [94], [95]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[96]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[97]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[98]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[99], [100]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[4], [101], [102]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[4], [103]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[104]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[108], [111], [113]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[116]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[117]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[4], [118], [119]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[14], [4], [120], [26], [121], [122]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[123]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[124]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[14], [4], [125]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[126]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[99], [127]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[1], [2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[128]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[129]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[130]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[131]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[133], [134]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[135]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[136], [137]
D1101		Naldemedine	C32H34N4O6	54732242	Major		Inter Info	[138]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[14], [139]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[14], [94], [95]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[1], [2], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[140]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[141]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[14], [4], [142]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[4], [143]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[14], [4], [144]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[14], [4], [145]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[146]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[4], [147]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[4], [149]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[150]
D1330		Praziquantel	C19H24N2O2	4891	Major		Inter Info	[151], [14], [152], [153]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[154]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[14], [155], [156], [157], [158]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[159]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[160]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[161]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[13], [14], [4], [162]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[4], [163]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[4], [164]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[165]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[166], [167]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[14], [4], [168]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[169]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[14], [4], [170]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[171]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[172], [14], [4], [173], [174], [175], [176], [177], [178], [179]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[180]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[181]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[4], [182], [183]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[14], [4], [184]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[185], [186]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[14], [187]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[4], [188]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[4], [189], [190]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[191]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[192]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[193]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[194]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[4], [195], [148]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[14], [4], [196]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[197]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[198]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[199]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[1], [2], [3]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[200], [201]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[1], [2], [3]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[202]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[203]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[205], [14], [4], [206], [207]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[208]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[14]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[209], [14], [72], [4], [210], [211], [212]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[258]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[259], [260], [25]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[14], [4], [261]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[21], [262], [263], [167], [27]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[24], [2], [264]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[265], [266]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[267]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[265], [268]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[285], [286], [257]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[287]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[217], [226], [250]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[14], [4], [261]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[14], [4], [261]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[288], [289], [290], [291]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[292], [293], [294], [295]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[260], [25]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[296]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[297], [298]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[299]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[300], [301]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[302], [303], [304], [305], [306]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[307]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[4]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[308]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[309]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[310]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [311]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[312]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[14], [4], [313]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[314]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[209], [14], [4]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[315], [316], [317], [318], [319]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[320]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[4], [321], [322], [323]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[321], [322], [323]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[324]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[325]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[326]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[14], [4], [261]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[14], [4], [261]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[217], [226], [250]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[217], [226], [250]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[217], [226], [250]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[327]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[328], [329], [330], [331], [332], [2], [333], [334]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[335]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[297], [298]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[336]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[337]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[14]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[338]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[339]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[340]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[342]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[300], [301]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[217], [226], [250]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[343]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[344], [345], [346], [347]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[344], [345], [346]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[348]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[349]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[350]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[351]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[352]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [353], [354], [355]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[356], [357], [358]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[359]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[360], [361]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[362]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[341]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[363]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[364]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[14], [4], [365]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4], [366], [367]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[368], [206], [369], [370]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[371], [372]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[373]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[374]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[260], [25]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[375], [376]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[377]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[269], [270], [271], [13], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[13], [14], [4]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[213], [214], [215], [216], [217], [218], [219], [220], [21], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [27], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[217], [226], [250]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[378], [379], [2], [380], [381], [382]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[383], [384], [385], [386]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[387]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[388]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[4], [389], [390], [391]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[370]
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[25]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[25]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[392]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[393], [120], [122]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[394], [395], [396], [397]
D1003		Mephenytoin	C12H14N2O2	4060	Minor		Inter Info	[25]
D1024		Methohexital	C14H18N2O3	9034	Minor		Inter Info	[25]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[25]
D0571		Enfortumab vedotin	NA	NA	Minor		Inter Info	[4], [398], [399], [400]
D0585		Eplerenone	C24H30O6	443872	Minor		Inter Info	[20], [14], [4], [401], [402]
D0621		Ethotoin	C11H12N2O2	3292	Minor		Inter Info	[25]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[25]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[403]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[25]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[404]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[25]
D1306		Polatuzumab vedotin	NA	NA	Minor		Inter Info	[14], [405]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[25]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[25]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[25]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[25]
D1573		Thiopental	C11H18N2O2S	3000715	Minor		Inter Info	[25]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[406], [407]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[204]

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82	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
83	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
84	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
85	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
86	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
87	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
88	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
89	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
90	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
91	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
92	Product Information. Zortress (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
93	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
94	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
95	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
96	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
97	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
98	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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103	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
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112	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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117	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
118	Portoles A, Terleira A, Calvo A, Martinez I, Resplandy G "Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial." J Clin Pharmacol 46 (2006): 1188-94. [PMID: 16988208]
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120	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
121	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
122	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
123	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
124	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
125	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
126	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
127	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
128	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
129	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
130	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
131	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
132	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
133	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
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135	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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138	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
139	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
140	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
141	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
142	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
143	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
144	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
145	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
146	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
147	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
148	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
149	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
150	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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155	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
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160	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
161	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
162	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
163	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
164	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
165	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
166	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
167	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
168	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
169	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
170	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
171	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
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181	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
182	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
183	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
184	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
185	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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188	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
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191	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
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193	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
194	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
195	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
196	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
197	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
198	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
199	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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333	Product Information. Rifamate (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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336	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
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350	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
351	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
352	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
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362	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
363	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
364	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
365	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
366	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
367	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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385	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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393	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
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400	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
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402	Product Information. Casodex (bicalutamide). Zeneca Pharmaceuticals, Wilmington, DE.
403	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
404	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
405	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
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